1 上海健康医学院上海市分子影像学重点实验室，上海 201318
2 上海健康医学院医学影像学院，上海 201318
3 海军军医大学第一附属医院，上海 200433
4 上海交通大学医学院附属瑞金医院核医学科，上海 200020
核医学成像设备中的探测器是整个设备的核心部件。基于闪烁体探测器的核医学成像设备存在光电转换效率低和能量分辨率差等关键问题，短期内难以有效解决。而近年来碲锌镉半导体探测器的发展使得核医学成像设备在能量分辨率和空间分辨率等方面取得了很大的提高。本文以单光子发射计算机断层成像(SPECT)技术为例，首先介绍了核医学成像原理及设备组成，然后从碲锌镉探测器的工作原理及基本结构出发，综述了碲锌镉探测器的新技术及其在临床核医学的应用，最后结合核医学领域应用的需求展望了碲锌镉探测器的研究重点和技术发展趋势。
碲锌镉 探测器 核医学 单光子发射计算机断层成像 能量分辨率 光电转换效率 cadmium zinc telluride detector nuclear medicine SPECT energy resolution photoelectric conversion efficiency
Author Affiliations
Abstract
1 State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
2 Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China
We present a facile and effective method for fabrication of the localized surface plasmon resonance (LSPR) optical fiber sensor assisted by two polydopamine (PDA) layers with enhanced plasmonic sensing performance. The first PDA layer was self-polymerized onto the bare optical fiber to provide the catechol groups for the reduction from Ag+ to Ago through chelating and redox activity. As the reduction of Ag+ proceeds, Ag nanoparticles (NPs) were grown in-situ on the PDA layer with uniform distribution. The second PDA layer was applied to prevent Ag NPs from oxidating and achieve an improvement of LSPR signal. The PDA/Ag/PDA-based optical fiber sensor has an enhanced LSPR sensitivity of 961 nm/RIU and excellent oxidation resistance. The stable PDA/Ag/PDA-based LSPR sensor with high optical performance is very promising for future application in optical sensing field.
LSPR optical fiber polydopamine in-situ growth silver nanoparticles Photonic Sensors
2020, 10(2): 97
